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Upregulated hepatic lipogenesis from dietary sugars in response to low palmitate feeding supplies brain palmitate

Biology

Upregulated hepatic lipogenesis from dietary sugars in response to low palmitate feeding supplies brain palmitate

M. E. Smith, C. T. Chen, et al.

This groundbreaking research by Mackenzie E. Smith and colleagues reveals how brain palmitic acid (PAM) is generated during development in mice, uncovering the role of de novo lipogenesis from dietary sugars in maintaining brain PAM levels, especially under low dietary PAM conditions. Interestingly, maternal behavior and pup development remained unaffected by dietary PAM variations.

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Playback language: English
Abstract
This study investigates the origin of brain palmitic acid (PAM) during development in mice fed diets with varying PAM levels. Using carbon isotope ratios, the researchers found that de novo lipogenesis (DNL) from dietary sugars maintains the majority of brain PAM, especially in mice fed low PAM. Upregulation of hepatic DNL genes in response to low PAM indicates a compensatory mechanism to maintain brain PAM pools. Maternal behavior and pup sensorimotor development were unaffected by dietary PAM levels.
Publisher
Nature Communications
Published On
Jan 17, 2024
Authors
Mackenzie E. Smith, Chuck T. Chen, Chiraag A. Gohel, Giulia Cisbani, Daniel K. Chen, Kimia Rezaei, Andrew McCutcheon, Richard P. Bazinet
Tags
palmitic acid
de novo lipogenesis
brain development
mice nutrition
dietary fats
compensatory mechanism

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