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Understanding and modeling human traits and diseases: Insights from the comparative genomics resources of Zoonomia

Biology

Understanding and modeling human traits and diseases: Insights from the comparative genomics resources of Zoonomia

M. Ye and D. Zhang

This groundbreaking research by Maosen Ye and Deng-Feng Zhang uncovers the genetic underpinnings of human traits and diseases using data from the Zoonomia Project. By scrutinizing evolutionary constraints across 240 mammalian genomes, the team reveals the critical roles of conserved genomic regions, coding and non-coding regions, and guides the development of better animal models for studying human diseases.

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