Engineering and Technology

Ultra-high gradient connectomics and microstructure MRI scanner for imaging of human brain circuits across scales

G. Ramos-llordén, H. Lee, et al.

We designed the Connectome 2.0 human MRI scanner with a head-only, 3-layer gradient coil delivering 500 mT m⁻¹ and 600 T m⁻¹ s⁻¹ (≈5× the performance of prior research systems) and integrated high-density 72‑channel in vivo and 64‑channel ex vivo RF coils with field monitoring. These advances yield up to 2× sensitivity gains and at least a 30% improvement over Connectome 1.0, enabling fine white‑matter pathway mapping and cellular- and axonal-scale inferences approaching single‑micron resolution. This research was conducted by Authors present in <Authors> tag.