Biology

Triangulating evidence from observational and Mendelian randomization studies of ketone bodies for cognitive performance

W. Sae-jie, S. Supasai, et al.

Investigating the impact of ketone bodies, specifically 3-β-hydroxybutyrate (BOHBUT), on cognitive function has yielded exciting results. This study, conducted by Wichanon Sae-Jie and colleagues, discovered a positive link between BOHBUT and cognitive health, suggesting its potential as an alternative energy source for the brain, especially in relation to Alzheimer's disease.

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Abstract

Ketone bodies (KBs), alternative brain energy sources when glucose is limited, are investigated for their association with cognitive function. This study triangulates observational and Mendelian randomization (MR) studies to examine the relationship between 3-β-hydroxybutyrate (BOHBUT), a major KB, and cognitive performance. Observational analyses in the Whitehall II study (5506 participants) revealed a positive association between BOHBUT and general cognitive function. Two-sample MR using summary statistics from large consortia confirmed a protective effect of BOHBUT on cognitive performance and Alzheimer's disease (AD). Cis-MR analysis of OXCT1, a gene involved in KB catabolism, showed limited evidence of therapeutic modulation. The findings suggest a beneficial role for BOHBUT in cognitive health.

Publisher

BMC

Published On

Aug 24, 2023

Authors

Wichanon Sae-Jie, Suangsuda Supasai, Mika Kivimaki, Jackie F Price, Andrew Wong, Meena Kumari, Jorgen Engmann, Tina Shah, Amand F Schmidt, Tom R Gaunt, Aroon Hingorani, Pimphen Charoen

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