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TomoTwin: generalized 3D localization of macromolecules in cryo-electron tomograms with structural data mining

Biology

TomoTwin: generalized 3D localization of macromolecules in cryo-electron tomograms with structural data mining

G. Rice, T. Wagner, et al.

Discover how Gavin Rice and colleagues have revolutionized cryogenic-electron tomography with TomoTwin, a cutting-edge deep metric learning model that accurately localizes macromolecules in complex cellular environments without the need for manual data training. This breakthrough enables de novo protein identification, making analysis of densely packed tomograms more efficient and reliable.

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