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The genetic determinants of language network dysconnectivity in drug-naïve early stage schizophrenia

Psychology

The genetic determinants of language network dysconnectivity in drug-naïve early stage schizophrenia

J. Du, L. Palaniyappan, et al.

This groundbreaking study by Jingnan Du, Lena Palaniyappan, and colleagues reveals the intricate language network dysconnectivity in early-stage schizophrenia, linking it to illness duration and genetic factors. A significant finding is the connection between polygenic risk scores related to FOXP2 genes and dysconnectivity in patients with shorter illness duration, emphasizing the critical nature of language processing in mental health.

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Playback language: English
Abstract
This study investigated language network dysconnectivity and its relationship with illness duration in early-stage schizophrenia. Two independent datasets of drug-naïve first-episode schizophrenia (FES) patients and healthy controls underwent brain-wide voxel-level functional connectivity analysis. Elevated functional connectivity involving Broca's area, thalamus, and temporal cortex was replicated across datasets. Broca's area-anterior cingulate cortex dysconnectivity was more pronounced in patients with shorter illness duration, while thalamic dysconnectivity was predominant in those with longer duration. Polygenic risk scores from FOXP2-related genes were strongly associated with functional dysconnectivity in patients with shorter illness duration. The findings highlight the importance of language network dysconnectivity in early schizophrenia and the role of language-related genes.
Publisher
npj Schizophrenia
Published On
Mar 03, 2021
Authors
Jingnan Du, Lena Palaniyappan, Zhaowen Liu, Wei Cheng, Weikang Gong, Mengmeng Zhu, Jijun Wang, Jie Zhang, Jianfeng Feng
Tags
schizophrenia
dysconnectivity
language network
illness duration
FOXP2 genes
functional connectivity
brain analysis
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