This paper investigates the impact of large-scale land-use modifications for climate mitigation (bioenergy with carbon capture and storage (BECCS) and afforestation) on global and regional biodiversity using an integrated model framework. The results show that while climate mitigation generally benefits global biodiversity, negative impacts are concentrated in regions with high land-use change and carbon sequestration. The study emphasizes the need for mitigation strategies that minimize land-use change and address the unequal regional distribution of benefits and costs.