Medicine and Health
Tau seeds occur before earliest Alzheimer's changes and are prevalent across neurodegenerative diseases
M. Manca, H. G. Standke, et al.
This groundbreaking study by authors from Case Western Reserve University and NIH highlights the ability of tau RT-QuIC assays to detect 3R/4R tau seeds in Alzheimer's disease well before traditional histopathological signs. The findings reveal a widespread presence of tau seeds across various neurodegenerative conditions, emphasizing their potential role in early diagnosis and understanding of disease progression.
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