Medicine and Health

Targeting the hypothalamus for modeling age-related DNA methylation and developing OXT-GnRH combinational therapy against Alzheimer's disease-like pathologies in male mouse model

S. S. Usmani, H. Jung, et al.

This groundbreaking study by Salman Sadullah Usmani and colleagues uncovers the critical role of the hypothalamus in age-related DNA methylation and showcases the astonishing effectiveness of OXT-GnRH combinational therapy in combating Alzheimer's disease-like symptoms.

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Abstract

This study investigates the role of the hypothalamus in age-related DNA methylation and explores the therapeutic potential of OXT-GnRH combinational therapy against Alzheimer's disease (AD)-like pathologies. Using bisulfite oligonucleotide-captured sequencing (BOCS), the researchers compared DNA methylation in the hypothalamus, hippocampus, and olfactory bulb of young and middle-aged mice. They found that the hypothalamus exhibits unique DNA methylation dynamics with age, particularly affecting OXT and GnRH pathways. In a 5xFAD AD mouse model, OXT-GnRH combination therapy proved significantly more effective than individual peptides in treating AD-like symptoms and reducing amyloid-beta plaques.

Publisher

Nature Communications

Published On

Oct 31, 2024

Authors

Salman Sadullah Usmani, Hyun-Gug Jung, Qichao Zhang, Min Woo Kim, Yuna Choi, Ahmet Burak Caglayan, Dongsheng Cai

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