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Abstract
This study investigates the role of the hypothalamus in age-related DNA methylation and explores the therapeutic potential of OXT-GnRH combinational therapy against Alzheimer's disease (AD)-like pathologies. Using bisulfite oligonucleotide-captured sequencing (BOCS), the researchers compared DNA methylation in the hypothalamus, hippocampus, and olfactory bulb of young and middle-aged mice. They found that the hypothalamus exhibits unique DNA methylation dynamics with age, particularly affecting OXT and GnRH pathways. In a 5xFAD AD mouse model, OXT-GnRH combination therapy proved significantly more effective than individual peptides in treating AD-like symptoms and reducing amyloid-beta plaques.
Publisher
Nature Communications
Published On
Oct 31, 2024
Authors
Salman Sadullah Usmani, Hyun-Gug Jung, Qichao Zhang, Min Woo Kim, Yuna Choi, Ahmet Burak Caglayan, Dongsheng Cai
Tags
hypothalamus
DNA methylation
Alzheimer's disease
OXT-GnRH therapy
amyloid-beta plaques
age-related pathologies
therapeutic potential

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