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TANGO1 inhibitors reduce collagen secretion and limit tissue scarring

Medicine and Health

TANGO1 inhibitors reduce collagen secretion and limit tissue scarring

I. Raote, A. Rosendahl, et al.

Researchers including Ishier Raote and Ann-Helen Rosendahl have developed innovative membrane-permeant peptide inhibitors that target the TANGO1-cTAGE5 interaction, crucial for collagen export. This study uncovers promising strategies to modulate ECM hypersecretion, significantly reducing excessive scarring and fibrosis in zebrafish and human dermal cells.

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