Medicine and Health

Systematic review and meta-analysis of AI-based conversational agents for promoting mental health and well-being

H. Li, R. Zhang, et al.

This systematic review and meta-analysis by Han Li, Renwen Zhang, Yi-Chieh Lee, Robert E. Kraut, and David C. Mohr finds AI-based conversational agents can significantly reduce symptoms of depression and distress—especially when multimodal, generative, and integrated with mobile messaging—while overall psychological well-being showed no significant change, pointing to the need for research on mechanisms, long-term effects, and safe LLM integration.