Chemistry

Synthesis of covalent organic pillars as molecular nanotubes with precise length, diameter and chirality

Y. Tian, Y. Guo, et al.

This exciting research unveils the creation of a novel discrete molecular nanotube, COP-1, synthesized via a unique [2+5] imine condensation reaction. Characterized and resolved enantiomerically, these nanotubes exhibit specific structural features that influence their interactions with disubstituted n-alkyl chains. Conducted by a team of researchers from Xiamen University and Tianjin University, this study opens new avenues in molecular design and synthesis.

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Abstract

This paper reports the synthesis of a discrete molecular nanotube, covalent organic pillar (COP-1), through a [2+5] imine condensation reaction. A pair of enantiomeric nanotubes were synthesized, characterized, and resolved. Studies revealed that the nanotube's 2-nm-long and 4.7-Å-wide channel accommodates α,ω-disubstituted n-alkyl chains of complementary lengths and electron density. Length mismatches resulted in altered binding and unfavorable conformations.

Publisher

Nature Synthesis

Published On

Feb 13, 2023

Authors

Yaru Tian, Yunlong Guo, Xue Dong, Xintong Wan, Kuan-Heng Cheng, Rong Chang, Shunshun Li, Xiaoyu Cao, Yi-Tsu Chan, Andrew C.-H. Sue

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