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Abstract
Psoriasis is a chronic inflammatory skin disease. This study investigated the effects of sulforaphane (SFN) on a mouse model of psoriasis and its molecular mechanism. SFN treatment improved psoriatic symptoms, reduced inflammation markers, and activated the KEAP1-NRF2 pathway. NRF2-deficient mice showed aggravated psoriasis, suggesting SFN's therapeutic potential via the KEAP1-NRF2 pathway.
Publisher
Cell Death and Disease
Published On
Nov 25, 2023
Authors
Chujun Ma, Chaode Gu, Panpan Lian, Junaid Wazir, Renwei Lu, Binjia Ruan, Lulu Wei, Li Li, Wenyuan Pu, Ziqi Peng, Wentong Wang, Yangyongyi Zong, Zhiqiang Huang, Hongwei Wang, Yan Lu, Zhonglan Su
Tags
Psoriasis
Sulforaphane
Inflammation
KEAP1-NRF2 pathway
Therapeutic potential
Mouse model
Chronic inflammatory skin disease

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