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Stress-induced vagal activity influences anxiety-relevant prefrontal and amygdala neuronal oscillations in male mice

Medicine and Health

Stress-induced vagal activity influences anxiety-relevant prefrontal and amygdala neuronal oscillations in male mice

T. Okonogi, N. Kuga, et al.

This groundbreaking study by Toya Okonogi and colleagues reveals the intricate relationship between the vagus nerve and anxiety. Through their research, they discovered that vagal activity correlates with anxiety behavior in mice, with fascinating implications for understanding mood disorders. Chronic stimulation appears to restore necessary neural oscillations, highlighting the essential connection between the vagus nerve and mental health.

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Playback language: English
Abstract
This study investigated the neurophysiological dynamics of the vagus nerve in response to anxiety. Researchers found that cervical vagus nerve spike rates correlated with anxiety behavior in mice, and these changes were absent in stress-susceptible mice. Vagus nerve spike rates negatively correlated with 2–4 Hz oscillations and positively with 20–30 Hz oscillations in the prefrontal cortex and amygdala. Chronic vagus nerve stimulation restored behavior-relevant neuronal oscillations in stress-susceptible mice, suggesting that vagal-brain communication is fundamental to anxiety and mood disorders.
Publisher
Nature Communications
Published On
Jan 09, 2024
Authors
Toya Okonogi, Nahoko Kuga, Musashi Yamakawa, Tasuku Kayama, Yuji Ikegaya, Takuya Sasaki
Tags
vagus nerve
anxiety
neurophysiology
mood disorders
neuronal oscillations
stress-susceptible
chronic stimulation

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