Chemistry

Species-specific lipophilicities of fluorinated diketones in complex equilibria systems and their potential as multifaceted reversible covalent warheads

I. Columbus, L. Ghindes-azaria, et al.

This groundbreaking research by Ishay Columbus and colleagues unveils the versatile physicochemical properties of fluorinated diketones (FDKs), highlighting their potential as reversible covalent warheads in drug development. Discover how the unique CF2(CO)2 group adapts to various environments, showcasing exciting shifts in lipophilicity that could revolutionize therapeutic strategies.

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