Medicine and Health

Smart drug delivery systems to overcome drug resistance in cancer immunotherapy

W. Yi, D. Yan, et al.

Discover how cutting-edge smart drug delivery systems (SDDSs) can tackle drug resistance in cancer immunotherapy. This research, conducted by Wenzhe Yi, Dan Yan, Dangge Wang, and Yaping Li, explores innovative strategies to enhance treatment efficacy by improving immune responses and reversing tumor microenvironments.

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Playback language: English

Index

Abstract

Cancer immunotherapy, while a significant advancement, faces challenges like drug resistance. This review explores how smart drug delivery systems (SDDSs) can overcome this resistance. SDDSs are designed for precise drug delivery, boosting efficacy by increasing drug concentration at target sites and improving immune responses. The authors discuss how SDDSs overcome resistance by combining immunogenic cell death with immunotherapy, reversing immunosuppressive tumor microenvironments, modulating the interferon signaling pathway, and improving cell therapy efficacy. Future perspectives on SDDS development for enhanced immunotherapy are also presented.

Publisher

Cancer Biology & Medicine

Published On

Jan 01, 2023

Authors

Wenzhe Yi, Dan Yan, Dangge Wang, Yaping Li

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