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SMARCB1 loss activates patient-specific distal oncogenic enhancers in malignant rhabdoid tumors

Medicine and Health

SMARCB1 loss activates patient-specific distal oncogenic enhancers in malignant rhabdoid tumors

N. Q. Liu, I. Paassen, et al.

This groundbreaking study by Ning Qing Liu and colleagues unveils how the loss of *SMARCB1* in malignant rhabdoid tumors leads to significant epigenetic changes, activating unique enhancer-promoter interactions with the *MYC* oncogene, revealing insights into personalized tumorigenesis in this aggressive childhood cancer.... show more
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Citations
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82
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Note: The citation metrics presented here have been sourced from Semantic Scholar and OpenAlex.

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