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Single-cell genomic profiling of human dopamine neurons identifies a population that selectively degenerates in Parkinson's disease

Medicine and Health

Single-cell genomic profiling of human dopamine neurons identifies a population that selectively degenerates in Parkinson's disease

T. Kamath, A. Abdulraouf, et al.

This groundbreaking study by Tushar Kamath, Abdulraouf Abdulraouf, and colleagues reveals crucial insights into the vulnerability of dopamine neurons in Parkinson's disease. By profiling over 387,000 nuclei, researchers uncovered a specific neuron population that is particularly susceptible to degeneration, highlighting significant genetic risks tied to this subtype. This research sheds light on the intrinsic mechanisms behind neuron loss in PD, a critical step towards understanding and treating the disease.

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