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Serotonin and psilocybin activate 5-HT1B receptors to suppress cortical signaling through the claustrum

Medicine and Health

Serotonin and psilocybin activate 5-HT1B receptors to suppress cortical signaling through the claustrum

M. B. Madden, C. Schaefgen, et al.

Serotonin and psilocybin suppress cortical signaling through the claustrum by activating presynaptic 5-HT1B receptors on anterior cingulate cortex inputs, suggesting a serotonin-mediated gain-control of cortical input that psilocybin may target to alter cortical network states. Research conducted by Maxwell B. Madden, Chloe Schaefgen, Binita Vedak, Jian Kwon, Kiara S. Dresp Pedra, Samuel H. Sheats, Adam C. Puche, Steffen B. E. Wolff, and Brian N. Mathur.... show more
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