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Sequence-based drug design as a concept in computational drug design

Medicine and Health

Sequence-based drug design as a concept in computational drug design

L. Chen, Z. Fan, et al.

Unveiling a groundbreaking approach in drug design, researchers propose a sequence-to-drug concept utilizing protein sequence information through end-to-end differentiable learning. This innovative method, validated with TransformerCPI2.0, demonstrates its potential to discover new drug hits and target existing drugs. Conducted by a dedicated team of researchers, this study offers an alternative to conventional drug development methodologies, especially for proteins lacking high-quality 3D structures.... show more
Citation Metrics
Citations
114
Influential Citations
6
Reference Count
77
Citation by Year

Note: The citation metrics presented here have been sourced from Semantic Scholar and OpenAlex.

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