Biology

SARS-CoV-2 variant biology: immune escape, transmission and fitness

A. M. Carabelli, T. P. Peacock, et al.

Explore the dynamic world of SARS-CoV-2 variants with insights from researchers Alessandro M Carabelli and colleagues. This review delves into the interplay between viral mutations and human immunity, revealing how these factors shape the future trajectory of COVID-19.

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Abstract

This review summarizes the literature on SARS-CoV-2 variants, focusing on their transmissibility, antigenicity, mutations (spike protein furin cleavage site and non-spike proteins), recombination, and evolution in the context of T cells, innate immunity, and population immunity. The interplay between virus biology and human immunity (vaccination and prior infection) significantly impacts the fitness of VOCs. The relationship between virus antigenicity, transmission, and virulence is complex and has unpredictable implications for COVID-19's future trajectory.

Publisher

Nature Reviews Microbiology

Published On

Mar 01, 2023

Authors

Alessandro M Carabelli, Thomas P Peacock, Lucy G Thorne, William T Harvey, Joseph Hughes, Sharon J Peacock, Wendy S Barclay, Thushan I De Silva, Greg J Towers, David L Robertson

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