Medicine and Health

SARS-CoV-2 genomic surveillance in wastewater as a model for monitoring evolution of endemic viruses

M. Yousif, S. Rachida, et al.

This groundbreaking study unveils the potential of wastewater surveillance in tracking SARS-CoV-2 variants in South Africa. By leveraging wastewater sequencing, the researchers—Mukhlid Yousif, Said Rachida, and others—identified multiple viral lineages often missed in clinical settings, providing a proactive signal for future lineage transitions.

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Abstract

This study investigated the use of wastewater surveillance to identify and characterize SARS-CoV-2 variants in South Africa. Wastewater sequencing analyses were found to be temporally concordant with clinical genomic surveillance, revealing multiple lineages not detected clinically. Wastewater genomics reliably recovered the prevalence of local circulating variants, even when clinical samples were unavailable, and provided a signal of upcoming lineage transitions. The study demonstrates the utility of wastewater genomics for monitoring the evolution and spread of endemic viruses.

Publisher

Nature Communications

Published On

Oct 10, 2023

Authors

Mukhlid Yousif, Said Rachida, Setshaba Taukobong, Nkosenhle Ndlovu, Chinwe Iwu-Jaja, Wayne Howard, Shelina Moonsamy, Nompilo Mhlambi, Sipho Gwala, Joshua I. Levy, Kristian G. Andersen, Cathrine Scheepers, Anne von Gottberg, Nicole Wolter, Jinal N. Bhiman, Daniel Gyamfi Amoako, Arshad Ismail, Melinda Suchard, Kerrigan McCarthy

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