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Role of T cells in severe COVID-19 disease, protection, and long term immunity

Biology

Role of T cells in severe COVID-19 disease, protection, and long term immunity

J. M. Hermens and C. Kesmir

Explore the fascinating interplay between T cells and COVID-19 severity in this insightful review by Julia Maret Hermens and Can Kesmir. Discover how specific T cell responses can provide long-term protection and how innovative vaccination strategies may enhance immunity against the virus.

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Playback language: English
Abstract
Infection with SARS-CoV-2 causes a wide range of disease severities. This review discusses the association between T cells and COVID-19 disease severity and protection upon re-exposure. While infiltration of overactivated cytotoxic T cells might be harmful, fast-responding T cells are crucial for protection against severe COVID-19. This protection could be long-term due to long-living memory T cells. Including N or M proteins in vaccinations, alongside the S protein, could broaden T cell response and improve protection.
Publisher
Immunogenetics
Published On
Feb 08, 2023
Authors
Julia Maret Hermens, Can Kesmir
Tags
SARS-CoV-2
T cells
COVID-19
immunity
vaccination
disease severity
memory T cells

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