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Abstract
The study investigates the functional humoral response induced by a plant-derived Coronavirus-like particle (CoVLP) COVID-19 vaccine candidate, with and without AS03 adjuvant. AS03-adjuvanted CoVLP induced robust and durable SARS-CoV-2 specific humoral immunity, characterized by strong IgG1 antibody responses, potent FcγR binding, and antibody effector function. FcγR2A-receptor binding and antibody-mediated effector functions like opsonophagocytosis remained detectable for at least six months, even as neutralizing antibody titers waned.
Publisher
npj Vaccines
Published On
Feb 13, 2023
Authors
Paulina Kaplonek, Deniz Cizmeci, Jessica Shih-Lu Lee, Sally A. Shin, Stephanie Fischinger, Philipe Gobeil, Stéphane Pillet, Nathalie Charland, Brian J. Ward, Galit Alter
Tags
COVID-19
vaccine
humoral immunity
Coronavirus-like particles
adjuvant
SARS-CoV-2
antibody response

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