RNA G-quadruplex in TMPRSS2 reduces SARS-CoV-2 infection

Index

Abstract

This study investigates the role of RNA G-quadruplex (RG4) in SARS-CoV-2 infection. Bioinformatics, biochemical, and biophysical assays reveal RG4s in the SARS-CoV-2 genome and host factors. A 3-quartet RG4 within TMPRSS2 inhibits its translation, preventing SARS-CoV-2 entry. G4 stabilizers attenuate SARS-CoV-2 infection in pseudovirus systems and mouse models. Increased TMPRSS2 protein levels are observed in COVID-19 patient lungs. These findings suggest RG4 as a potential target for COVID-19 prevention and treatment.

Publisher

Nature Communications

Published On

Mar 17, 2022

Authors

Geng Liu, Wenya Du, Xiongbo Sang, Qiyu Tong, Ye Wang, Guoqing Chen, Yi Yuan, Lili Jiang, Wei Cheng, Dan Liu, Yan Tian, Xianghui Fu

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