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Reliability of high-quantity human brain organoids for modeling microcephaly, glioma invasion and drug screening

Medicine and Health

Reliability of high-quantity human brain organoids for modeling microcephaly, glioma invasion and drug screening

A. Ramani, G. Pasquini, et al.

Hi-Q brain organoids reproducibly generate thousands of uniform, functional human brain models from multiple hiPSC lines, overcoming size and cellular heterogeneity, cellular stress, and variability. They support cryopreservation and re-culturing, recapitulate patient-specific developmental defects (CDK5RAP2-related microcephaly and Cockayne syndrome), and enabled a medium-throughput screen that identified Selumetinib and Fulvestrant as inhibitors of glioma invasion in vivo. Research conducted by the authors listed in the <Authors> tag.

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~3 min • Beginner • English
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Citations
11
Influential Citations
1
Reference Count
75
Citation by Year

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