This paper introduces a fiber optic probe-based Raman imaging system for real-time molecular virtual reality data visualization. The system combines Raman spectroscopy with computer vision-based positional tracking, photometric stereo, and augmented/mixed chemical reality to enable molecular imaging and visualization of 3D surface boundaries. It achieves a spatial resolution of 0.5 mm and a topology resolution of 0.6 mm, with a spectral sampling frequency of 10 Hz. Applications on biological samples (pharmaceutical compounds, brain tumor phantom, sarcomas) demonstrate its suitability for clinical tissue-boundary demarcation.
Publisher
Light: Science & Applications
Published On
Apr 26, 2022
Authors
Wei Yang, Florian Knorr, Ines Latka, Matthias Vogt, Gunther O. Hofmann, Jürgen Popp, Iwan W. Schie
Tags
Raman spectroscopy
molecular imaging
fiber optic probe
augmented reality
real-time visualization
clinical applications
tissue boundaries
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