Medicine and Health

Real-time molecular imaging of near-surface tissue using Raman spectroscopy

W. Yang, F. Knorr, et al.

This innovative research led by Wei Yang, Florian Knorr, Ines Latka, Matthias Vogt, Gunther O. Hofmann, Jürgen Popp, and Iwan W. Schie introduces a groundbreaking fiber optic probe-based Raman imaging system. It enables real-time molecular visualizations of tissue boundaries, achieving unparalleled spatial and topology resolution through advanced techniques in augmented chemical reality. Experience the future of molecular imaging applied to clinical tissue assessment.

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Abstract

This paper introduces a fiber optic probe-based Raman imaging system for real-time molecular virtual reality data visualization. The system combines Raman spectroscopy with computer vision-based positional tracking, photometric stereo, and augmented/mixed chemical reality to enable molecular imaging and visualization of 3D surface boundaries. It achieves a spatial resolution of 0.5 mm and a topology resolution of 0.6 mm, with a spectral sampling frequency of 10 Hz. Applications on biological samples (pharmaceutical compounds, brain tumor phantom, sarcomas) demonstrate its suitability for clinical tissue-boundary demarcation.

Publisher

Light: Science & Applications

Published On

Apr 26, 2022

Authors

Wei Yang, Florian Knorr, Ines Latka, Matthias Vogt, Gunther O. Hofmann, Jürgen Popp, Iwan W. Schie

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