Rational design of *N*-heterocyclic compound classes via regenerative cyclization of diamines

This paper introduces a novel three-component reaction for the rational design and synthesis of *N*-heterocyclic compounds using a regenerative cyclization approach. The reaction utilizes a manganese-based catalyst to dehydrogenate an amino alcohol, which then undergoes condensation and cyclization with a diamine to form a new pair of amines. This pair then undergoes ring closure with an aldehyde, carbonyldiimidazole, or a dehydrogenated amino alcohol. The reaction is diastereoselective, has a broad scope, and tolerates many functional groups. The synthesized *N*-heterocyclic compounds, including a new class termed 'fertigines', are novel and have not been previously reported.

Robin Fertig, Felix Leowsky-Künstler, Torsten Irrgang, Rhett Kempe