Medicine and Health

Rapid evolution of A(H5N1) influenza viruses after intercontinental spread to North America

A. Kandeil, C. Patton, et al.

Discover the alarming expansion of highly pathogenic avian influenza A(H5N1) viruses in 2021, as detected in North America. This groundbreaking research by Ahmed Kandeil and colleagues reveals the complexities of reassortment and the severe impact of these viruses on mammals, highlighting the urgent need for strategies to combat their evolution and potential pandemic risk.

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Abstract

Highly pathogenic avian influenza A(H5N1) viruses of clade 2.3.4.4b expanded geographically in 2021. By late 2021, these viruses were detected in North America, leading to reassortment with North American wild bird viruses. This reassortment resulted in genetically and phenotypically diverse A(H5N1) viruses, many causing severe disease and neurological involvement in mammals. The reassortment potential and neurotropism of the current A(H5N1) 2.3.4.4b lineage necessitate strategies to combat its spread and evolution and mitigate the risk of a pandemic.

Publisher

Nature Communications

Published On

May 29, 2023

Authors

Ahmed Kandeil, Christopher Patton, Jeremy C. Jones, Trushar Jeevan, Walter N. Harrington, Sanja Trifković, Jon P. Seiler, Thomas Fabrizio, Karlie Woodard, Jasmine C. Turner, Jeri-Carol Crumpton, Lance Miller, Adam Rubrum, Jennifer DeBeauchamp, Charles J. Russell, Elena A. Govorkova, Peter Vogel, Mia Kim-Torchetti, Yohannes Berhane, David Stalknecht, Rebecca Poulson, Lisa Kercher, Richard J. Webby

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