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Abstract
This study validates a nuclease-activatable fluorescent probe, P2&3TT, for rapid and culture-independent detection of Staphylococcus aureus (S. aureus) in blood cultures. The probe leverages the specific nuclease activity of S. aureus to produce a detectable fluorescence signal. Results show that P2&3TT successfully differentiates S. aureus-positive blood cultures from those positive for other pathogens or negative cultures, suggesting its potential for clinical implementation in diagnosing staphylococcal bacteremia.
Publisher
Scientific Reports
Published On
Oct 26, 2020
Authors
Author Name 1, Author Name 2
Tags
Staphylococcus aureus
nuclease-activatable probe
blood cultures
fluorescent detection
clinical diagnostics

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