This systematic review examines the efficacy of psilocybin-assisted psychotherapy in treating depression. Eight studies were included, revealing significant and sustained reductions in depressive symptoms after one or two psilocybin sessions, even in treatment-resistant cases. The role of the therapist in establishing a therapeutic alliance and integrating the psychedelic experience is highlighted. While adverse effects were generally mild and transient, limitations include a small number of studies, geographic bias, and potential expectancy effects. Future research should explore different psychotherapy approaches and the role of spiritual experiences.
Publisher
Behav. Sci.
Published On
Mar 31, 2023
Authors
Dawood Hristova, Pérez-Jover
Tags
psilocybin
psychotherapy
depression
therapeutic alliance
treatment-resistant
psychedelic experience
systematic review
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