This study reports a systematic review and meta-analysis of microbiota-targeted (psychobiotics) interventions on anxiety in youth, including youth consultation on intervention acceptability. A meta-analysis of 10 studies (324 experimental, 293 control subjects) found no overall effect of psychobiotics on anxiety (pooled SMD = −0.03, 95% CI: −0.21, 0.14). Sensitivity analysis accounting for risk of bias suggested minimal efficacy (−0.16, 95% CI: −0.38, 0.07). The authors conclude that current evidence is limited, and future research should focus on specifying mechanisms, causal understanding, and wider context.
Publisher
Translational Psychiatry
Published On
Mar 17, 2021
Authors
Kathrin Cohen Kadosh, Melissa Basso, Paul Knytl, Nicola Johnstone, Jennifer Y. F. Lau, Glenn R. Gibson
Tags
psychobiotics
anxiety
youth
microbiota
systematic review
meta-analysis
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