Psychology

Psychobiotic interventions for anxiety in young people: a systematic review and meta-analysis, with youth consultation

K. C. Kadosh, M. Basso, et al.

Explore the intriguing world of psychobiotics and their impact on youth anxiety in this systematic review by authors Kathrin Cohen Kadosh, Melissa Basso, Paul Knytl, Nicola Johnstone, Jennifer Y. F. Lau, and Glenn R. Gibson. Despite including youth perspectives on intervention acceptability, the findings reveal limited overall effects, challenging our understanding of microbiota-targeted interventions.

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Playback language: English

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Abstract

This study reports a systematic review and meta-analysis of microbiota-targeted (psychobiotics) interventions on anxiety in youth, including youth consultation on intervention acceptability. A meta-analysis of 10 studies (324 experimental, 293 control subjects) found no overall effect of psychobiotics on anxiety (pooled SMD = −0.03, 95% CI: −0.21, 0.14). Sensitivity analysis accounting for risk of bias suggested minimal efficacy (−0.16, 95% CI: −0.38, 0.07). The authors conclude that current evidence is limited, and future research should focus on specifying mechanisms, causal understanding, and wider context.

Publisher

Translational Psychiatry

Published On

Mar 17, 2021

Authors

Kathrin Cohen Kadosh, Melissa Basso, Paul Knytl, Nicola Johnstone, Jennifer Y. F. Lau, Glenn R. Gibson

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