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Pseudotyped Bat Coronavirus RaTG13 is efficiently neutralised by convalescent sera from SARS-CoV-2 infected patients

Medicine and Health

Pseudotyped Bat Coronavirus RaTG13 is efficiently neutralised by convalescent sera from SARS-CoV-2 infected patients

D. Cantoní, M. Mayora-neto, et al.

In a surprising revelation, researchers, including Diego Cantoní and Martin Mayora-Neto, discovered that antibodies from SARS-CoV-2 infection or vaccination neutralize RaTG13 more efficiently than SARS-CoV-2. Their work suggests that current vaccination strategies could potentially mitigate future RaTG13 spillover, raising important implications for public health.

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Playback language: English
Abstract
RaTG13, a close relative of SARS-CoV-2, shares high genomic similarity. This study investigated whether antibodies from SARS-CoV-2 infection or vaccination neutralize RaTG13. Surprisingly, RaTG13 was more efficiently neutralized than SARS-CoV-2 by convalescent sera. Neutralization assays using spike mutants revealed that both spike proteins tolerate multiple changes without significantly impacting neutralization. The E484K mutation increased RaTG13 neutralization but decreased SARS-CoV-2 neutralization. These findings suggest current SARS-CoV-2 vaccination strategies might mitigate future RaTG13 spillover.
Publisher
Communications Biology
Published On
May 03, 2022
Authors
Diego Cantoní, Martin Mayora-Neto, Nazia Thakur, Ahmed M. E. Elrefaey, Joseph Newman, Sneha Vishwanath, Angalee Nadesalingam, Andrew Chan, Peter Smith, Javier Castillo-Olivares, Helen Baxendale, Bryan Charleston, Jonathan Heeney, Dalan Bailey, Nigel Temperton
Tags
RaTG13
SARS-CoV-2
neutralization
vaccination
spillover
antibodies
mutations

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