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Preventing and treating PTSD-like memory by trauma contextualization

Psychology

Preventing and treating PTSD-like memory by trauma contextualization

A. S. A. Abed, E. Ducourneau, et al.

Exciting new research by Alice Shaam Al Abed and colleagues reveals that contextual amnesia plays a crucial role in PTSD-like memory formation in mice. Remarkably, re-exposure to trauma-related cues can reverse PTSD-like hypermnesia. This groundbreaking study highlights potential therapeutic approaches focusing on trauma contextualization and hippocampal mechanisms.... show more
Abstract
Post-traumatic stress disorder (PTSD) is characterized by emotional hypermnesia on which preclinical studies focus so far. While this hypermnesia relates to salient traumatic cues, partial amnesia for the traumatic context can also be observed. Here, we show in mice that contextual amnesia is causally involved in PTSD-like memory formation, and that treating the amnesia by re-exposure to all trauma-related cues cures PTSD-like hypermnesia. These findings open a therapeutic perspective based on trauma contextualization and the underlying hippocampal mechanisms.
Publisher
Nature Communications
Published On
Aug 24, 2020
Authors
Alice Shaam Al Abed, Eva-Gunnel Ducourneau, Chloé Bouarab, Azza Sellami, Aline Marighetto, Aline Desmedt
DOI
https://doi.org/10.1038/s41467-020-18002-w
Tags
PTSD
memory formation
contextual amnesia
hypermnesia
hippocampus
trauma
cues

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