This study investigated the neural changes in the prefrontal cortex during working memory training and how these changes transfer between active and passive tasks. Two monkeys were trained on a visual working memory task across four phases of increasing complexity. Neural activity was recorded using a chronic electrode array in the prefrontal cortex. The results showed that training-induced changes in neuronal activation, noise correlation, and local field potential (LFP) power in the active task were also observed in a passive control task. These findings suggest that working memory training induces lasting changes in the prefrontal circuitry that generalize across tasks.

Hua Tang, Christos Constantinidis