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Predictive chemoproteomics and functional validation reveal Coeae6g-mediated insecticide cross-resistance in the malaria vector Anopheles gambiae
BiologyNature Communications

Predictive chemoproteomics and functional validation reveal Coeae6g-mediated insecticide cross-resistance in the malaria vector Anopheles gambiae

S. Balaska, L. Grigoraki, et al.

A predictive chemoproteomic framework combining competitive activity‑based protein profiling and functional validation was applied to a susceptible Anopheles gambiae strain, revealing 18 active serine hydrolases and identifying carboxylesterase Coeae6g as conferring resistance to pirimiphos‑methyl and cross‑resistance to malathion, bendiocarb, and permethrin — a scalable approach to anticipate enzyme‑mediated resistance and inform insecticide management. Research conducted by Sofia Balaska, Linda Grigoraki, Gareth Lycett, David Weetman, Folasade Oladepo, Fraser Colman, John Vontas, Mark J. I. Paine, and Hanafy M. Ismail.... show more
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