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Abstract
This study investigated whether a prebiotic diet (3% galacto-oligosaccharide/fructo-oligosaccharide) could mitigate the effects of *in utero* valproic acid (VPA) exposure in a mouse model of autism spectrum disorder (ASD). Male offspring of VPA- or PBS-exposed dams were fed either a control or prebiotic diet from birth. The prebiotic diet normalized VPA-induced alterations in gut microbiota, intestinal permeability, peripheral immune homeostasis, cerebellar neuroinflammation, and impairments in social behavior and cognition. These findings suggest that dietary interventions may offer a potential treatment strategy for ASD.
Publisher
Acta Pharmacologica Sinica
Published On
Apr 08, 2024
Authors
Naika Prince, Lucia N Peralta Marzal, Anastasia Markidi, Sabbir Ahmed, Youri Adolfs, R Jeroen Pasterkamp, Himanshu Kumar, Guus Roeselers, Johan Garssen, Aletta D Kraneveld, Paula Perez-Pardo
Tags
prebiotic diet
valproic acid
autism spectrum disorder
gut microbiota
neuroinflammation
dietary intervention
social behavior

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