Medicine and Health

Prebiotic diet normalizes aberrant immune and behavioral phenotypes in a mouse model of autism spectrum disorder

N. Prince, L. N. P. Marzal, et al.

This groundbreaking study explores how a prebiotic diet can counteract the negative effects of in utero valproic acid exposure in autism spectrum disorder, revealing potential dietary interventions for improving gut health and behavior. The research was conducted by Naika Prince, Lucia N Peralta Marzal, Anastasia Markidi, Sabbir Ahmed, Youri Adolfs, R Jeroen Pasterkamp, Himanshu Kumar, Guus Roeselers, Johan Garssen, Aletta D Kraneveld, and Paula Perez-Pardo.

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Abstract

This study investigated whether a prebiotic diet (3% galacto-oligosaccharide/fructo-oligosaccharide) could mitigate the effects of *in utero* valproic acid (VPA) exposure in a mouse model of autism spectrum disorder (ASD). Male offspring of VPA- or PBS-exposed dams were fed either a control or prebiotic diet from birth. The prebiotic diet normalized VPA-induced alterations in gut microbiota, intestinal permeability, peripheral immune homeostasis, cerebellar neuroinflammation, and impairments in social behavior and cognition. These findings suggest that dietary interventions may offer a potential treatment strategy for ASD.

Publisher

Acta Pharmacologica Sinica

Published On

Apr 08, 2024

Authors

Naika Prince, Lucia N Peralta Marzal, Anastasia Markidi, Sabbir Ahmed, Youri Adolfs, R Jeroen Pasterkamp, Himanshu Kumar, Guus Roeselers, Johan Garssen, Aletta D Kraneveld, Paula Perez-Pardo

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