Medicine and Health

Pleiotropic Effects of Sodium-Glucose Cotransporter-2 Inhibitors in Cardiovascular Disease and Chronic Kidney Disease

A. Rastogi and J. L. J. Jr

Sodium-glucose cotransporter-2 inhibitors (SGLT2is) are revolutionizing the management of cardiovascular and renal health, showcasing significant benefits for patients with heart failure and chronic kidney disease, irrespective of diabetes status. Discover the extensive mechanisms behind these remarkable outcomes in the research conducted by A Rastogi and James L Januzzi Jr.

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Playback language: English

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Abstract

Sodium-glucose cotransporter-2 inhibitors (SGLT2is) improve cardiovascular and renal outcomes in patients with cardiovascular disease, chronic kidney disease (CKD), and heart failure (HF), regardless of type 2 diabetes (T2D) status. Their benefits extend beyond glucose reduction, encompassing effects on intraglomerular pressure, preload/afterload, potassium levels, left ventricular function, sympathetic nervous system activity, hematologic parameters, uric acid levels, and potentially anti-inflammatory properties. This review explores the multifaceted mechanisms underlying these cardiorenal benefits.

Publisher

Journal of Clinical Medicine

Published On

Apr 12, 2023

Authors

A Rastogi, James L Januzzi Jr

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