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Personalized brain circuit scores identify clinically distinct biotypes in depression and anxiety

Psychology

Personalized brain circuit scores identify clinically distinct biotypes in depression and anxiety

L. Tozzi, X. Zhang, et al.

Discover groundbreaking insights from a study conducted by Leonardo Tozzi and colleagues, which reveals how personalized brain circuit dysfunction scores can help categorize patients with depression and anxiety into distinct biotypes, each linked to unique symptoms and treatment responses.

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Playback language: English
Abstract
This study aimed to develop quantitative measures of brain circuit dysfunction to stratify patients with depression and anxiety. Using fMRI data from 801 treatment-free patients and 250 patients after treatment randomization, personalized scores of brain circuit dysfunction were derived. Participants were categorized into six biotypes based on intrinsic functional connectivity and task-evoked activation and connectivity. These biotypes showed distinct symptom profiles, behavioral test performance, and treatment responses, providing a new, theory-driven, clinically validated method to address the heterogeneity of depression and anxiety.
Publisher
Nature Medicine
Published On
Jul 01, 2024
Authors
Leonardo Tozzi, Xue Zhang, Adam Pines, Alisa M. Olmsted, Emily S. Zhai, Esther T. Anene, Megan Chesnut, Bailey Holt-Gosselin, Sarah Chang, Patrick C. Stetz, Carolina A. Ramirez, Laura M. Hack, Mayuresh S. Korgaonkar, Max Wintermark, Ian H. Gotlib, Jun Ma, Leanne M. Williams
Tags
brain circuit dysfunction
depression
anxiety
fMRI
biotypes
treatment response

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