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Abstract
This study investigates the association between peripheral blood mononuclear cell (PBMC) respiratory function and progressive glaucoma. Lower PBMC oxygen consumption rate (OCR) is strongly linked to faster visual field progression in IOP-lowering treated patients (P<0.001). OCR is lower in glaucoma patients than controls (P<0.001) and lower in patients with low baseline IOP than those with high IOP (P<0.01). PBMC nicotinamide adenine dinucleotide (NAD) levels are also lower in glaucoma patients (P<0.001) and strongly associated with OCR (P<0.001). The findings suggest PBMC OCR and NAD levels as potential biomarkers for progressive glaucoma.
Publisher
Nature Medicine
Published On
Aug 01, 2024
Authors
Bledi Petriti, Alessandro Rabiolo, Kai-Yin Chau, Pete A. Williams, Giovanni Montesano, Gerassimos Lascaratos, David F. Garway-Heath
Tags
glaucoma
peripheral blood mononuclear cells
oxygen consumption rate
NAD levels
visual field progression
biomarkers

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