Psychology

Patterns of brain asymmetry associated with polygenic risks for autism and schizophrenia implicate language and executive functions but not brain masculinization

Z. Sha, D. Schijven, et al.

This study by Zhiqiang Sha, Dick Schijven, and Clyde Francks explores the intriguing links between polygenic risk scores for autism spectrum disorder and schizophrenia with brain asymmetries in over 32,000 UK Biobank participants. The findings reveal unique brain asymmetry patterns tied to each disorder, highlighting the roles of language and executive functions.

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Abstract

This study investigated the multivariate associations of polygenic risk scores for autism spectrum disorder (ASD) and schizophrenia with brain asymmetries in 32,256 UK Biobank participants. Results showed distinct patterns of brain asymmetry associated with each disorder, implicating language and executive functions but not supporting the hypothesis of brain masculinization or feminization in their etiologies.

Publisher

Molecular Psychiatry

Published On

Jul 01, 2021

Authors

Zhiqiang Sha, Dick Schijven, Clyde Francks

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