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Abstract
Delayed cerebral ischemia (DCI) is a common and serious complication of aneurysmal subarachnoid hemorrhage (aSAH). This review examines the pathophysiology of DCI and its association with early brain injury (EBI). Recent studies highlight EBI as the primary contributor to DCI development. New predictive models, including advanced monitoring and neuroimaging, aid in EBI detection and management. EBI severity, SAH severity, and physiological/imaging markers offer potential targets for early aSAH therapeutics. Research should focus on microcellular milieu and hemodynamic mechanisms to improve outcomes for aSAH patients.
Publisher
Journal of Clinical Medicine
Published On
Jan 28, 2023
Authors
Diana L Alsbrook, Mario Di Napoli, Kunal Bhatia, Masoom Desai, Archana Hinduja, Clio A Rubinos, Gelsomina Mansueto, Puneetpal Singh, Gustavo G Domeniconi, Asad Ikram, Sara Y Sabbagh, Afshin A Divani
Tags
Delayed cerebral ischemia
early brain injury
aneurysmal subarachnoid hemorrhage
predictive models
therapeutics
neuroimaging
microcellular milieu

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