Medicine and Health

Pathophysiology of Early Brain Injury and Its Association with Delayed Cerebral Ischemia in Aneurysmal Subarachnoid Hemorrhage: A Review of Current Literature

D. L. Alsbrook, M. D. Napoli, et al.

Discover how delayed cerebral ischemia (DCI) is intricately linked to early brain injury (EBI) following aneurysmal subarachnoid hemorrhage (aSAH). This cutting-edge review unveils new predictive models and potential therapeutic targets for enhancing patient outcomes. Conducted by a diverse team of experts, this research shines a light on vital mechanisms that could change the future of aSAH treatment.

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Playback language: English

Index

Abstract

Delayed cerebral ischemia (DCI) is a common and serious complication of aneurysmal subarachnoid hemorrhage (aSAH). This review examines the pathophysiology of DCI and its association with early brain injury (EBI). Recent studies highlight EBI as the primary contributor to DCI development. New predictive models, including advanced monitoring and neuroimaging, aid in EBI detection and management. EBI severity, SAH severity, and physiological/imaging markers offer potential targets for early aSAH therapeutics. Research should focus on microcellular milieu and hemodynamic mechanisms to improve outcomes for aSAH patients.

Publisher

Journal of Clinical Medicine

Published On

Jan 28, 2023

Authors

Diana L Alsbrook, Mario Di Napoli, Kunal Bhatia, Masoom Desai, Archana Hinduja, Clio A Rubinos, Gelsomina Mansueto, Puneetpal Singh, Gustavo G Domeniconi, Asad Ikram, Sara Y Sabbagh, Afshin A Divani

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