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Pathogenic bacteria remodel central metabolic enzyme to build a cyclopropanol warhead
BiologyNature Chemistry

Pathogenic bacteria remodel central metabolic enzyme to build a cyclopropanol warhead

F. Trottmann, K. Ishida, et al.

Discover how Burkholderia pseudomallei uses the enzyme BurG to fabricate essential cyclopropanol rings in virulence-inducing malleicyprols. This groundbreaking research, conducted by Felix Trottmann, Keishi Ishida, Mie Ishida-Ito, Hajo Kries, Michael Groll, and Christian Hertweck, unveils a hidden pathway of metabolic evolution potentially ripe for antivirulence strategies.... show more
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