Medicine and Health

Optimization of the spherical integrity for sustained-release alginate microcarriers-encapsulated doxorubicin by the Taguchi method

C. T. Pan, S. T. Chien, et al.

This groundbreaking study by C. T. Pan and colleagues delves into optimizing biodegradable calcium alginate microcarriers for effective and sustained doxorubicin delivery in hepatocellular carcinoma treatment. Achieving uniformity and extending drug release for two weeks while maintaining microcarrier non-toxicity underscores a promising advancement in transarterial chemoembolization methodologies.

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Abstract

This study aimed to optimize biodegradable calcium alginate microcarriers for sustained-release doxorubicin delivery in transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC). Using the Taguchi method, eight parameters were optimized to achieve uniform particle size and spherical integrity. The optimal parameters yielded microcarriers with sustained drug release for about two weeks and reduced cell viability in HCC cell lines. The microcarriers themselves showed non-toxicity.

Publisher

Scientific Reports

Published On

Dec 10, 2020

Authors

C. T. Pan, S. T. Chien, T. C. Chiang, C. K. Yen, S. Y. Wang, Z. H. Wen, C. Y. Yu, Y. L. Shiue

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