Psychology

Not all smokers are alike: the hidden cost of sustained attention during nicotine abstinence

H. U. Deshpande, J. R. Fedota, et al.

Discover how nicotine withdrawal affects cognitive function in smokers. This research, conducted by Harshawardhan U. Deshpande and colleagues, reveals that smokers with lower task performances show increased difficulties in attention following abstinence. The study highlights the importance of focused interventions for those most impacted by nicotine withdrawal.

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Playback language: English

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Abstract

This study investigated the heterogeneity of nicotine withdrawal syndrome (NWS)-associated cognitive deficits in smokers. Smokers completed a Parametric Flanker Task (PFT) during fMRI sessions under nicotine-sated and abstinent conditions. Based on PFT performance, smokers were divided into high (HTP) and low task performer (LTP) subgroups. HTPs showed greater vulnerability to abstinence-induced errors of omission and greater BOLD responses in attentional control regions. Functional connectivity analysis revealed abstinence-induced FC strength increases only in HTPs, correlated with errors of omission. The study suggests that HTP smokers demonstrate sustained attention deficits following abstinence, highlighting the need for targeted interventions.

Publisher

Neuropsychopharmacology

Published On

Jan 28, 2022

Authors

Harshawardhan U. Deshpande, John R. Fedota, Juan Castillo, Betty Jo Salmeron, Thomas J. Ross, Elliot A. Stein

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