Early cancer detection could significantly reduce mortality. This study uses the Taizhou Longitudinal Study (TZL) data, analyzing plasma samples from 605 asymptomatic individuals (191 later diagnosed with cancer) and 232 cancer patients, plus tissue samples. The PanSeer blood test, based on circulating tumor DNA methylation, detected five common cancers in 88% of post-diagnosis patients (96% specificity) and 95% of asymptomatic individuals who later developed cancer. This suggests potential for non-invasive cancer detection up to four years before conventional diagnosis.
Publisher
Nature Communications
Published On
Oct 26, 2020
Authors
Xingdong Chen, Jeffrey Gole, Arthurva Gore, Qiye He, Ming Lu, Jun Min, Ziyu Yuan, Xiaorong Yang, Yanfeng Jiang, Tiejun Zhang, Chen Suo, Xiaojie Li, Lei Cheng, Zhenhua Zhang, Hongyu Niu, Zhe Li, Zhen Xie, Han Shi, Xiang Zhang, Min Fan, Xiaofeng Wang, Yajun Yang, Justin Dang, Catie McConnell, Juan Zhang, Jiucun Wang, Shunzhang Yu, Weimin Ye, Yuan Gao, Kun Zhang, Rui Liu, Li Jin
Tags
cancer detection
plasma samples
blood test
asymptomatic individuals
tumor DNA methylation
non-invasive diagnosis
Related Publications
Explore these studies to deepen your understanding of the subject.
