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NMDARs activation regulates endothelial ferroptosis via the PP2A-AMPK-HMGB1 axis

Medicine and Health

NMDARs activation regulates endothelial ferroptosis via the PP2A-AMPK-HMGB1 axis

W. Han, Y. Hong, et al.

This groundbreaking study by Wei-Min Han, Yi-Xiang Hong, Guo-Sheng Xiao, Rui-Ying Wang, and Gang Li uncovers how N-methyl-D-aspartate receptor (NMDAR) activation triggers ferroptosis in vascular endothelial cells, revealing critical pathways and potential therapeutic targets to mitigate endothelial injury.

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