This study investigates the role of myofiber necroptosis in muscle regeneration. Researchers found that MLKL-dependent necroptosis in myofibers after muscle injury is crucial for effective regeneration. Inhibition of necroptosis or genetic ablation of MLKL in myofibers resulted in impaired muscle regeneration. Necroptotic myofibers release factors, including Tenascin-C (TNC), into the muscle stem cell (MuSC) microenvironment. TNC, released via necroptotic membrane rupture, promotes MuSC proliferation by activating the EGFR signaling pathway. This research highlights the unexpected beneficial role of necroptosis in muscle regeneration.

Shen'ao Zhou, Wei Zhang, Gaihong Cai, Yingzhe Ding, Caixia Wei, Sheng Li, Yu Yang, Jie Qin, Dan Liu, Hao Zhang, Xiexiang Shao, Jianhua Wang, Hongye Wang, Wenjun Yang, Huating Wang, She Chen, Ping Hu, Liming Sun